Article ID Journal Published Year Pages File Type
10822543 Current Opinion in Structural Biology 2013 7 Pages PDF
Abstract
► Molten globules known to bind ligands include binding proteins and a designed enzyme. ► On ligand binding: binding proteins remain molten; designed enzyme folds. ► Conformational entropy of side chains found by NMR line broadening. ► Changes in entropy upon effector binding, though far from site, help to drive binding.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Molten globules, entropy-driven conformational change and protein folding
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