| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10822552 | Current Opinion in Structural Biology | 2013 | 8 Pages |
Abstract
⺠Islet amyloid contributes to type-2 diabetes and to islet transplant failure. ⺠IAPP is natively unfolded, but is one of the most amyloidogenic proteins known. ⺠High resolution models of IAPP amyloid fibers are available. ⺠Anionic lipids and glycosaminoglycans catalyze IAPP amyloid formation in vitro. ⺠There are multiple mechanisms of IAPP induced β-cell toxicity.
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Authors
Ping Cao, Andisheh Abedini, Daniel P Raleigh,