Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10822558 | Current Opinion in Structural Biology | 2013 | 9 Pages |
Abstract
⺠The WHD of type IIA topoisomerases exhibits a non-canonical DNA-binding mode. ⺠Packing of the two WHDs defines the cleavage pattern of type IIA topoisomerases. ⺠The wing-2 region of IIA enzyme's WHD mediates G-segment-bending. ⺠The Rossmann-like TOPRIM domain involves in catalysis as well as DNA-binding. ⺠The IIA enzyme-DNA interface can be targeted by antibiotics and anticancer drugs.
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Authors
Chih-Chiang Chang, Ying-Ren Wang, Shin-Fu Chen, Chyuan-Chuan Wu, Nei-Li Chan,