Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10822578 | Current Opinion in Structural Biology | 2013 | 9 Pages |
Abstract
Here, we review recent advances towards the modelling of protein-protein interactions (PPI) at the coarse-grained (CG) level, a technique that is now widely used to understand protein affinity, aggregation and self-assembly behaviour. PPI models of soluble proteins and membrane proteins are separately described, but we note the parallel development that is present in both research fields with three important themes: firstly, combining CG modelling with knowledge-based approaches to predict and refine protein-protein complexes; secondly, using physics-based CG models for de novo prediction of protein-protein complexes; and thirdly modelling of large scale protein aggregates.
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Authors
Marc Baaden, Siewert J Marrink,