Article ID Journal Published Year Pages File Type
10822637 Current Opinion in Structural Biology 2009 6 Pages PDF
Abstract
Investigations into protein folding have concentrated on experimentally tractable proteins with the result that membrane protein folding remains unsolved. New evidence is providing insight into the nature of the interactions stabilising the folded state of α-helical membrane proteins as well as giving hints on the character of the folding transition state. These developments show that classical methods used for water-soluble proteins can be successfully adapted for membrane proteins. The advances, coupled with increasing numbers of solved crystal structures, augur well for future research into the mechanisms of membrane protein folding.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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