Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10822703 | Current Opinion in Structural Biology | 2005 | 8 Pages |
Abstract
Aromatic polyketides are secondary metabolites that afford some of the most common antibiotics and anti-cancer drugs currently in clinical use. Not least because of their medical importance, the biosynthesis of these compounds has attracted considerable interest during the past few years; important advances have been made in the structural and mechanistic characterisation of the enzymes involved. These studies are expected to have implications for the production of novel therapeutic agents by combinatorial biosynthesis.
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Authors
Gunter Schneider,