Article ID Journal Published Year Pages File Type
10822705 Current Opinion in Structural Biology 2005 6 Pages PDF
Abstract
Chaperonins are molecular machines that facilitate protein folding by undergoing energy (ATP)-dependent movements that are coordinated in time and space by complex allosteric regulation. Recently, progress has been made in describing the various functional (allosteric) states of these machines, the pathways by which they interconvert, and the coupling between allosteric transitions and protein folding reactions. However, various mechanistic issues remain to be resolved.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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