Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10822755 | Current Opinion in Structural Biology | 2005 | 8 Pages |
Abstract
Recently, advances have been made in methods and applications that integrate electron microscopy density maps and comparative modeling to produce atomic structures of macromolecular assemblies. Electron microscopy can benefit from comparative modeling through the fitting of comparative models into electron microscopy density maps. Also, comparative modeling can benefit from electron microscopy through the use of intermediate-resolution density maps in fold recognition, template selection and sequence-structure alignment.
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Authors
Maya Topf, Andrej Sali,