Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10822786 | Current Opinion in Structural Biology | 2005 | 5 Pages |
Abstract
Computational methods are being developed both to detect the binding surfaces of individual macromolecules and to predict the structure of binary macromolecular complexes. Speeding up and refining this process has required work on search algorithms, molecular representations and interaction potentials. Although backbone flexibility and solvent effects continue to pose problems, encouraging results have been obtained for both protein-protein and protein-DNA complexes.
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Authors
Cyril Deremble, Richard Lavery,