| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823360 | DNA Repair | 2013 | 10 Pages |
Abstract
- Escherichia coli DinB and human pol κ discriminate against major groove modified DNA bases.
- Activity is lowest with DNA templates containing ÉdA compared to N6-furfuryl-dA.
- Dpo4 is more accommodating of these modified bases than DinB or pol κ.
- DinB R35A mutation eliminates discrimination against N6-furfuryl-dA.
Keywords
Related Topics
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Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Jason M. Walsh, Paul J. Ippoliti, Erin A. Ronayne, Eriks Rozners, Penny J. Beuning,