Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10823378 | DNA Repair | 2013 | 17 Pages |
Abstract
DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple forms, and if allowed to persist, can promote genome instability and directly lead to various human diseases, particularly cancer, neurological abnormalities, immunodeficiency and premature aging. To avoid such deleterious outcomes, cells have evolved an array of DNA repair pathways, which carry out what is typically a multiple-step process to resolve specific DNA lesions and maintain genome integrity. To fully appreciate the biological contributions of the different DNA repair systems, one must keep in mind the cellular context within which they operate. For example, the human body is composed of non-dividing and dividing cell types, including, in the brain, neurons and glial cells. We describe herein the molecular mechanisms of the different DNA repair pathways, and review their roles in non-dividing and dividing cells, with an eye toward how these pathways may regulate the development of neurological disease.
Keywords
SDSANEIL1AP endonuclease 1topoisomerase 1TC-NERSSBRXRCC1TFIIHGG-NERO6-methylguanine-DNA methyltransferasePUA6-4PPsCPDsDSBRDNA-PKcsPARP1Tyrosyl-DNA phosphodiesterase 1RNAPPCNAN-methylpurine-DNA glycosylasePNKPendonuclease VIII-like 1transcription factor II Hsynthesis-dependent strand annealingAPTXtranscription-coupled NERX-Ray Repair Cross-Complementing Protein 1APE1SCAN1AOA1AprataxinFEN1TDP1UngNth1MPGCSRMMRNSCSSAHNPCCDRPRPASCIDRFCMGMTTTDNHEJTop1OGG18-oxoguanine DNA glycosylaseapurinic/apyrimidinicataxia telangiectasia mutatedDNA single strand breaksDNA double strand break repairDNA polymerase βNERxeroderma pigmentosumSSBstrichothiodystrophyRNA polymeraseEndogenous DNA damageproliferating cellular nuclear antigenNeurological disorderDARSingle-strand annealingclass switch recombinationionizing radiationDNA repairnucleotide excision repairmismatch repairreplication protein AATMCyclobutane pyrimidine dimersHereditary Nonpolyposis Colorectal CancerNeural cellsNeural stem cellsCockayne syndromeReplication factor CPhosphoglycolateFlap endonuclease 1MUTYHmapHomologous recombinationDNA-dependent protein kinase catalytic subunitpol βPoly(ADP-ribose) polymerase-1MUTYH-associated polyposisNonhomologous end joiningERCC1severe combined immunodeficientUracil-DNA glycosylase
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Authors
Teruaki Iyama, David M. III,