| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823402 | DNA Repair | 2013 | 6 Pages |
Abstract
⺠BRCA2 and the RAD51 paralogs were down-regulated in human cells using siRNA. ⺠Epistatic interactions were examined by cellular responses to mitomycin C. ⺠BRCA2 knockdown imparts greater sensitivity than any individual RAD51 paralog. ⺠BRCA2 is epistatic to RAD51B, RAD51C, RAD51D, and XRCC3. ⺠BRCA2 and RAD51 paralog knockdown results in loss of viability in U2OS cells.
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Authors
Ryan B. Jensen, Ali Ozes, Taeho Kim, Allison Estep, Stephen C. Kowalczykowski,