| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823407 | DNA Repair | 2013 | 9 Pages |
Abstract
⺠The role of 8-oxoG repair by OGG1 in allergic airway inflammation was established. ⺠Inflammation was induced by intranasal ragweed pollen challenge of sensitized mice. ⺠Pollen exposure and infiltrating neutrophils increase 8-oxoG levels in the genome. ⺠Repair of 8-oxoG only under neutrophilia resulted in DNA single-strand breaks. ⺠Down-regulation of OGG1 in the airways decreased allergic immune responses.
Keywords
FapyGDSBAHRAPE1H2DCF-DAOGG1MEF8-oxoGBERAECs2,6-diamino-4-hydroxy-5-formamidopyrimidine7,8-dihydro-8-oxoguanine8-oxoguanine DNA glycosylase 18-oxoguanineapurinic/apyrimidinic siteNAD(P)H oxidaseNOxROSSSBsOxidative DNA damageAllergic inflammationBALFDNA repairbase excision repairOxidative stressComet assayAP sitesAirway epithelial cellssingle-strand breaksdouble-strand breakmurine embryonic fibroblastBronchoalveolar lavage fluidAirway hyperresponsivenessReactive oxygen species
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Authors
Attila Bacsi, Leopoldo Aguilera-Aguirre, Bartosz Szczesny, Zsolt Radak, Tapas K. Hazra, Sanjiv Sur, Xueqing Ba, Istvan Boldogh,