| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823440 | DNA Repair | 2012 | 12 Pages |
Abstract
⺠Expression of C. elegans APN-1 in yeast requires a nuclear localization signal. ⺠We purified APN-1 and show that it has four DNA repair activities. ⺠APN-1 is distinct from the previously characterized DNA repair enzyme EXO-3. ⺠APN-1 has unique roles in DNA repair. ⺠APN-1 repairs a broader range of base lesions as compared to other members.
Keywords
5-OHUEndo IVɛCɛA8oxoGApurinic/apyrimidinic sitesUDG3,N4-ethenocytosineAP EndonucleaseDHU5-hydroxyuracilMMSPMSFC. elegansDTTTHFSDS1,N6-ethenoadenine5,6-dihydrouracil8-oxoguanineUracil DNA glycosylaseOxidative DNA damageEndonuclease IVTetrahydrofuranDNA repairBase-excision repairmutationsdithiothreitolAP sitessodium dodecyl sulfateMethyl methane sulfonatepolymerase chain reactionPCR
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Authors
Xiaoming Yang, Jinjiang Fan, Alexander A. Ishchenko, Devang Patel, Murat K. Saparbaev, Dindial Ramotar,