Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10823491 | DNA Repair | 2012 | 11 Pages |
Abstract
⺠Reversibility of senescence in yeast cells was tested using two approaches. ⺠Despite telomere damage, most cells were viable after telomerase reactivation. ⺠Mating of senescent cells with normal cells also restored growth capability. ⺠Rescue by telomerase differed in checkpoint mutants and recombination mutants. ⺠Cells rescued by telomerase exhibited shortened telomeres.
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Authors
Sandra C. Becerra, Hiranthi T. Thambugala, Alison Russell Erickson, Christopher K. Lee, L. Kevin Lewis,