| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823493 | DNA Repair | 2012 | 12 Pages |
Abstract
⺠TBAPE1 is the main abasic site endonuclease in Trypanosoma brucei. ⺠TBAPE1 localizes in the cell nucleus of bloodstream and procyclic forms. ⺠Bloodstream TBAPE1-null mutants are viable but accumulate abasic DNA damage. ⺠Depletion of TBAPE1 renders cells sensitive to abasic and strand break-inducing drugs.
Keywords
APE1ExoIIIpolynucleotide kinase phosphatasePNKPPhleomycinEndoIVTDP1Nth1Exonuclease III3′-PAP EndonucleaseCPTEndonuclease IIIBSDHYGBERTrypanosoma bruceiMMSMTXMxAPLMOGG18-oxoguanine DNA glycosylase 1apurinic/apyrimidinicEndonuclease IVAP siteStrand breakMethotrexateMethoxyamineMethyl methanesulphonateNitric oxidehygromycin phosphotransferasecamptothecin
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Authors
Karen S. Charret, Cristina E. Requena, VÃctor M. Castillo-Acosta, Luis M. Ruiz-Pérez, Dolores González-Pacanowska, Antonio E. Vidal,