| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823494 | DNA Repair | 2012 | 9 Pages |
Abstract
⺠In this study we determine the crystal structures of TREX1 mutants linked to autoimmune disease. ⺠The structures reveal changes in the architecture of the active site that explain loss of catalytic activity. ⺠The structures also reveal conformational movement that is required for catalytic activity. ⺠Based on our cumulative work we propose a mechanism for catalysis for TREX1. ⺠The structures provide insight into dysfunction relating to human disease.
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Authors
Suzanna L. Bailey, Scott Harvey, Fred W. Perrino, Thomas Hollis,