| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823518 | DNA Repair | 2011 | 9 Pages |
Abstract
⺠Pol ζ participates in translesion synthesis (TLS) of DNA adducts that stall replication fork progression. ⺠We quantified bypass of abasic sites, cis-syn cyclobutane pyrimidine dimers and (6-4) photoproducts. ⺠In reactions containing high dNTP concentrations, L979F Pol ζ bypasses all three lesions. ⺠Wild-type Pol ζ also bypasses these lesions, with lower efficiencies. ⺠Our data supports the hypothesis that Pol ζ has the potential to be the sole DNA polymerase involved in TLS.
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Authors
Jana E. Stone, Dinesh Kumar, Sara K. Binz, Aki Inase, Shigenori Iwai, Andrei Chabes, Peter M. Burgers, Thomas A. Kunkel,