| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823520 | DNA Repair | 2011 | 13 Pages |
Abstract
⺠OxLDL promotes induction of pATM and p21 in fibroblasts/endothelial cells. ⺠OxLDL activates ATM-kinase by a doubled-stranded DNA break-independent mechanism. ⺠ATM-deficient fibroblasts exhibit low cell viability but increased oxidative stress towards oxLDL. ⺠ATM expression exerts protective effects against ox-LDL-induced cellular toxicity.
Keywords
phosphorylated H2AXDcfEA.hy926 cellsA-Tcarboxy-H2DCFDAPDTCγ-H2AXdichlorofluoresceinDSBsP21oxLDLAtaxia telangiectasia3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide5-(and-6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetateModified LDLMTTROSHydrogen peroxideAtherosclerosisATMpyrrolidine dithiocarbamateOxidized low-density lipoproteinLow-density lipoproteinLDLPatmReactive oxygen species
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Authors
Michaela Semlitsch, Rodney E. Shackelford, Sandra Zirkl, Wolfgang Sattler, Ernst Malle,