| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10823524 | DNA Repair | 2011 | 10 Pages |
Abstract
- OGG1 has been implicated in trinucleotide repeat expansion.
- The activity of OGG1 is not influenced by DNA sequence context.
- DNA structure does modulate activity of OGG1.
- This structure-dependent activity can lead to an accumulation of DNA damage in trinucleotide repeat sequences.
Keywords
TRISapurinicdimethoxytritylDNA ligase IIIFEN1TNRAPE1OGG1hOGG18-oxoGBERDMTPAGE8-oxo-7,8-dihydroguanineBSAbovine serum albuminEDTAEthylenediaminetetraacetic acidpolyacrylamide gel electrophoresisHuntington's diseaseTris(hydroxymethyl)aminomethanebase excision repairtrinucleotide repeatTrinucleotide repeat expansionMelting TemperatureFlap endonuclease 1pol βpolymerase β
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Authors
Daniel A. Jarem, Nicole R. Wilson, Kelly M. Schermerhorn, Sarah Delaney,