Article ID Journal Published Year Pages File Type
10825009 Journal of Biochemical and Biophysical Methods 2005 12 Pages PDF
Abstract
We consider a novel 2-D graphical representation of DNA sequences according to chemical structures of bases, reflecting distribution of bases with different chemical structure, preserving information on sequential adjacency of bases, and allowing numerical characterization. The representation avoids loss of information accompanying alternative 2-D representations in which the curve standing for DNA overlaps and intersects itself. Based on this representation we present a numerical characterization approach by the leading eigenvalues of the matrices associated with the DNA sequences. The utility of the approach is illustrated on the coding sequences of the first exon of human β-globin gene.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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