| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10826045 | Methods | 2013 | 12 Pages |
Abstract
⺠Single molecule/particle force spectroscopy (SMFS/SPFS) is introduced. ⺠SMFS/SPFS is used to investigate clathrin triskelia and clathrin assemblies. ⺠Cooperative unfolding of clathrin alpha-helix hairpin domains is revealed. ⺠Force spectra of triskelia and clathrin coats provide characteristic fingerprints. ⺠SPFS with varying force loading rate differentiates protein-protein interactions.
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Authors
Albert J. Jin, Eileen M. Lafer, Jennifer Q. Peng, Paul D. Smith, Ralph Nossal,