Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10826682 | Methods | 2005 | 8 Pages |
Abstract
Administration of a therapeutic antibody can lead to an anti-antibody response (AAR). Much effort has been applied to engineering antibodies with as little as possible non-human structure to minimize such responses. Here, we review reported AAR to murine, mouse-human chimeric, and humanized antibodies. Replacement of mouse immunoglobulin constant regions with human ones effects the largest immunogenicity reduction. Humanization of variable domains effects a further decrease.
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Authors
William Ying Khee Hwang, Jefferson Foote,