Article ID Journal Published Year Pages File Type
10827104 Microvascular Research 2012 8 Pages PDF
Abstract
► Expression of VEGF, PEDF and PACAP decreases with age. ► PEDF and VEGF increase at 18 and 24 months of age in rat brain microvessels. ► Acetaminophen improves oxidative stress-induced decreases in VEGF, PEDF and PACAP. ► Thrombin mediates the effect of acetaminophen on endothelial cell VEGF levels.
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