| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10827106 | Microvascular Research | 2012 | 9 Pages |
Abstract
⺠Protective action in endothelial cells (EC) of β-carotene is poorly understood. ⺠This study was to examine the HDL-like mechanisms of β-carotene in EC. ⺠β-carotene increased the expression of PONâ1, and reduced the expression of ICAM-1. ⺠β-carotene also induced p-AMPK, phospho-eNOS and PON-1 proteins. ⺠β-carotene may contribute to the maintenance of EC in a manner similar to HDL.
Keywords
HDLPSD-95/DLG/ZO-1PON-1VCAM-1RCTPDGFIL-1βCaMKIIeNOSApoA-IMCP-1ICAM-1PI3Khigh-density lipoproteinApolipoprotein A-IInterleukin-1 betaendothelial nitric oxide synthaseplatelet-derived growth factorPhosphatidylinositol 3-kinaseintercellular adhesion molecule-1Vascular cell adhesion molecule 1Paraoxonase-1monocyte chemoattractant protein 1reverse cholesterol transport
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Authors
Kazuo Yamagata, Noriko Tanaka, Hiroshi Matsufuji, Makoto Chino,