| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10827138 | Microvascular Research | 2012 | 4 Pages |
Abstract
⺠We investigated the relevance of oxidative stress in hypoxia-induced barrier disruption using an in vitro model. ⺠Prolonged hypoxic exposure induced reactive oxygen species formation and induced glutathione oxidation. ⺠Pro-oxidant treatment significantly disrupted barrier function under normal conditions whereas anti-oxidant treatment maintained better barrier function and cell survival in an O2-reduced environment. ⺠The endothelial response to oxidative stress was modulated by the presence of astrocytes and pericytes.
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Authors
Abraham Al Ahmad, Max Gassmann, Omolara O. Ogunshola,