Article ID Journal Published Year Pages File Type
10827148 Microvascular Research 2012 9 Pages PDF
Abstract
►Focal LPS delivery into microvessels of isolated lungs by microcatheter. ►Infused fluorescently-labeled autologous leukocytes into LPS-treated vessels. ►Intravital microscopy of leukocyte transit through lung microvessels. ►LPS increased leukocyte retention in pulmonary venules and capillaries. ►Endothelial TLR4 and ICAM-1 inhibition blocked leukocyte retention.
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