| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10827160 | Microvascular Research | 2012 | 6 Pages |
Abstract
⺠We examined maleimide-based small molecule GNX-686 as anti-angiogenic agent in vitro and in vivo. ⺠GNX-686 significantly inhibits the tube formation of HUVEC at 4 μM. ⺠In the CAM model, GNX-686 inhibits the developmental angiogenesis as effectively as bevacizumab. ⺠GNX-686 reduces retinal microvasculature in the mouse ROP model.
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Authors
Patrycja Nowak-Sliwinska, Mariangela Storto, Tiziana Cataudella, Jean-Pierre Ballini, Randall Gatz, Marco Giorgio, Hubert van den Bergh, Simon Plyte, Georges Wagnières,