| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10827164 | Microvascular Research | 2012 | 7 Pages |
Abstract
⺠Endothelial cells responses in conditioned media of HNSCC exposed to cetuximab. ⺠Cetuximab decreases proangiogenic factor secretion in conditioned media. ⺠Conditioned media increase network formation and modify endothelial EGFR expression. ⺠Targeted therapies as cetuximab can modify indirectly endothelial cells behavior. ⺠Proangiogenic factor decrease is not sufficient to obtain an antiangiogenic response.
Keywords
EGFRHUVECFCSFGF-2heat inactivated fetal calf serumVEGFR-2VEGF-AIL-8PECAM-1HNSCCInterleukin-8conditioned mediaHuman umbilical vein endothelial cellsvascular endothelial growth factor-Afibroblast growth factor-2platelet endothelial cell adhesion molecule-1Head and neck squamous cell carcinomaVascular endothelial growth factor receptor-2Epidermal growth factor receptor
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Authors
Valérie Jouan-Hureaux, Cédric Boura, Jean-Louis Merlin, Béatrice Faivre,