Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10827171 | Microvascular Research | 2012 | 9 Pages |
Abstract
⺠Maxadilan and PACAP-38 caused plasma leakage and leukocyte accumulation in postcapillary venules. ⺠Neutrophil migration induced by maxadilan was inhibited by PAC1- and CXCR2-antagonists. ⺠Four drugs with different mechanism of action inhibited both plasma leakage and leukocyte accumulation. ⺠A positive linear correlation between plasma leakage and leukocyte accumulation was observed during 30 min after its initiation.
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Authors
Erik Svensjö, Elvira M. Saraiva, Rafael Silveira Amendola, Christina Barja-Fidalgo, Marcelo T. Bozza, Ethan A. Lerner, Mauro M. Teixeira, Julio Scharfstein,