Article ID Journal Published Year Pages File Type
10827172 Microvascular Research 2012 6 Pages PDF
Abstract
► This study examined the role of ANP and its receptors to the modulation of LPS-induced lung injury. ► Inhibition of NPR-A augmented LPS-induced EC permeability and blocked protective effects of exogenous ANP. ► Inhibition of ANP clearance receptor NPR-C attenuated LPS-induced barrier disruptive effects. ► In vivo NPR-A inhibitor exacerbated LPS-induced lung injury, whereas inhibition of NPR-C suppressed LPS-induced lung injury.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Opposite effects of ANP receptors in attenuation of LPS-induced endothelial permeability and lung injury
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