| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10827190 | Microvascular Research | 2012 | 11 Pages |
Abstract
⺠Ischemic preconditioning (IP) reduced the size of myocardial no-reflow after ischemia and reperfusion. ⺠The eNOS inhibitor L-NNA completely neutralized the effects of IP without any influence on PKA activity. ⺠The PKA inhibitor H-89 partially reversed the IP-induced cardioprotection and eNOS activation. ⺠eNOS is essential for IP against myocardial no-reflow after ischemia and reperfusion. ⺠The cardioprotection of IP relates to PKA-mediated eNOS phosphorylation at Ser1179 and Ser635.
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Authors
Xiang-Dong Li, Yu-Tong Cheng, Yue-Jin Yang, Xian-Min Meng, Jing-Lin Zhao, Hai-Tao Zhang, Yong-Jian Wu, Shi-Jie You, Yi-Ling Wu,