Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population

Article ID	Journal	Published Year	Pages	File Type
10833467	Molecular Genetics and Metabolism	2012	5 Pages	PDF

Abstract

âº p.Pro70Leu, p.Ser195Leu, p.Ile441Thr, and p.Thr488Ala of FMO3 were identified. âº Recombinantly expressed FMO3 variants showed abnormal trimethylamine N-oxygenation. âº These missense but rare FMO3 mutations could be causative of trimethylaminuria.

Keywords

Trimethylaminuria Fish odor syndrome trimethylamine Flavin-containing monooxygenase Japanese

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Preview

Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population

Authors

Makiko Shimizu, Yuko Kobayashi, Shoko Hayashi, Yuka Aoki, Hiroshi Yamazaki,