| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10833475 | Molecular Genetics and Metabolism | 2012 | 8 Pages |
Abstract
⺠Brain bioenergetics was evaluated in brain of Gcdh â/â mice ⺠Respiratory chain complexes activities were only mildly altered ⺠Na+, K+- ATPase activity and expression were inhibited in cerebral cortex ⺠Disruption of Na+, K+- ATPase is suggested as a mechanism for cortical damage in GA I
Keywords
HEPESN-[2-hydroxyethyl]piperazine-N′-[2-ethane-sulfonic acid]α-KGDHGCDHDCIPDNPSPSSRT-qPCREGTATCAα-ketoglutarate dehydrogenaseEDTAethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid3-hydroxyglutaric acidethylenediaminetetracetic acidtricarboxylic acidglutaric acidBrain bioenergeticsStatistical Package for the Social SciencesdichloroindophenoldinitrophenolLysineLYSknockoutGlutaric acidemia type Iwild typequantitative real time polymerase chain reactionCreatine kinaseglutaryl-CoA dehydrogenase
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Authors
Alexandre Umpierrez Amaral, Bianca Seminotti, Cristiane Cecatto, Carolina Gonçalves Fernandes, Estela Natacha Brandt Busanello, Ãngela Zanatta, Luiza Wilges Kist, MaurÃcio Reis Bogo, Diogo Onofre Gomes de Souza, Michael Woontner, Stephen Goodman,