Article ID Journal Published Year Pages File Type
1083350 Journal of Clinical Epidemiology 2009 6 Pages PDF
Abstract

ObjectiveIt is often repeated that a low P-value provides more persuasive evidence for a genuine effect if the power of the test is high. However, this is based on an argument which ignores the precise P-value in favor of simply observing whether P is less than some cut-off, and which oversimplifies the possible effect sizes. In a non-Bayesian framework, there are good reasons to think that power does not affect the evidence of a given P-value. Here I illustrate the relationship between pre-study power and the Bayesian interpretation of a P-value in realistic situations.Study Design and SettingA Bayesian calculation, using a conventional prior distribution for the effect size and a normal approximation to the sampling distribution of the sample estimate, where the datum is the precise P-value.ResultsOver the range of pre-study powers typical in published research, the Bayesian interpretation of a given P-value varies little with power.ConclusionA Bayesian analysis with reasonable assumptions produces results remarkably in line with a more simple, non-Bayesian intuition—that the evidence against the null hypothesis provided by a precise P-value should not depend on power.

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Health Sciences Medicine and Dentistry Public Health and Health Policy
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