Akt inactivation induces endoplasmic reticulum stress-independent autophagy in fibroblasts from patients with Pompe disease

Article ID	Journal	Published Year	Pages	File Type
10833513	Molecular Genetics and Metabolism	2012	6 Pages	PDF

Abstract

âº Induction of ER stress-independent autophagy was observed in Pompe fibroblasts. âº Inactivation of Akt was observed in patient fibroblasts lacking ER stress. âº Activation of Akt suppressed the induction of autophagy in patient fibroblasts. âº Insulin improved the localization of rhGAA with lysosomes in patient fibroblasts.

Keywords

Akt Autophagy insulin Pompe disease Glycogen storage disease type II

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Akt inactivation induces endoplasmic reticulum stress-independent autophagy in fibroblasts from patients with Pompe disease

Authors

Yurika Nishiyama, Yohta Shimada, Takayuki Yokoi, Hiroshi Kobayashi, Takashi Higuchi, Yoshikatsu Eto, Hiroyuki Ida, Toya Ohashi,