Article ID Journal Published Year Pages File Type
10833538 Molecular Genetics and Metabolism 2012 8 Pages PDF
Abstract
► AACS mRNA levels are increased in the mice that were fed hypocholesterolemic agents. ► SREBP-2 interacts with the promoter region of AACS gene. ► Knockdown of SREBP-2 reduces mRNA levels of AACS. ► Knockdown of AACS results in a decrease in total serum cholesterol.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels
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