| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10833541 | Molecular Genetics and Metabolism | 2012 | 9 Pages |
Abstract
⺠An Aβ42-GFP fusion misfolds in transgenic plant cells and loses fluorescence. ⺠An Aβ42-HPTII fusion misfolds in plant cells with a loss of hygromycin resistance. ⺠A missense Aβ42 to replace Aβ42 rescues the functionality of the fusion proteins. ⺠Known anti-Aβ42-aggregation agents restore GFP fluorescence/hygromycin resistance. ⺠The system can serve to screen for inhibitors of Aβ42 misfolding (AD therapeutics).
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Authors
Tiehan Zhao, Ying Zeng, Allison R. Kermode,