| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10833742 | Molecular Genetics and Metabolism | 2012 | 12 Pages |
Abstract
⺠Unsatisfactory outcome in Classic Galactosemia calls for a more effective therapy. ⺠Human galactokinase (GALK) provides a validated target for intervention. ⺠Experimental and computational HTS for GALK inhibitors were performed. ⺠Characterization and optimization of selected positives identified promising leads. ⺠GALK inhibitors can be developed into novel antimicrobials/anti-cancer therapies.
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Authors
M. Tang, S.I. Odejinmi, H. Vankayalapati, K.J. Wierenga, K. Lai,