Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10833866 | Molecular Genetics and Metabolism | 2011 | 6 Pages |
Abstract
Since truncation of PC1/3 in its C-terminal region reportedly renders the enzyme unstable, we speculate that the accentuated processing of the triple variant in this region may, in vivo, create a subtle deficit of PC1/3 enzymatic activity in endocrine and neuroendocrine cells, causing impaired processing of prohormones and proneuropeptides to their bioactive forms.
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Authors
Majambu Mbikay, Francine Sirois, Kabwe K. Nkongolo, Ajoy Basak, Michel Chrétien,