| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10833886 | Molecular Genetics and Metabolism | 2012 | 9 Pages |
Abstract
⺠BHMT expression is repressed in homocystinuric mice and induced by betaine. ⺠Homocystinuric mice exhibit a decreased biochemical response to betaine over time. ⺠Decreased efficacy of betaine was due at least in part, to reduced BHMT activity. ⺠Higher Hcy causes TNF-a, IL-1a induction and a hypercoagulative phenotype. ⺠There is a sharp threshold effect between Hcy and thrombotic risk in homocystinuria.
Keywords
AdoMetALTHCUCBSAdoHcyHcyBetaine-homocysteine S-methyltransferaseBHMTMTHFRNF-kappaBS-adenosylhomocysteineCGLGNMTIL-1bAlanine aminotransferaseS-adenosylmethionineinterleukin-1betaCystathionine beta-synthaseCystathionine gamma-lyasenuclear factor-kappaBclassical homocystinuriahomocysteineglycine N-methyltransferase
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Kenneth N. Maclean, Hua Jiang, Lori S. Greiner, Robert H. Allen, Sally P. Stabler,