| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10834451 | Molecular Genetics and Metabolism | 2008 | 4 Pages |
Abstract
The purpose was to study the effect of PCSK9 46L on cholesterol concentration and cardiovascular morbidity. By comparing 176 carriers with 6618 non-carriers identified through a cross-sectional population study (WOBASZ) we confirmed the LDL lowering effect of PCSK9 46L and demonstrated that it increases with the concentration of LDL. We noted that PCSK9 46L was associated with tendency for protection from myocardial infarction but not stroke suggesting a difference in the effect on susceptibility to these disorders.
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Authors
Grażyna Kostrzewa, Grażyna Broda, PaweŠKurjata, Walerian Piotrowski, Rafal Ploski,