| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835114 | Nitric Oxide | 2012 | 9 Pages |
Abstract
⺠PA28 binds to the 20S proteasome and increases its ability to degrade small peptides. ⺠Expression of PA28 subunits (α, β, γ) is induced by interferon-γ stimulation. ⺠We show that NO inhibits a PA28-mediated increase in 26S proteasome activity in VSMC. ⺠NO decreased levels of PA28 subunits in balloon-injured arteries. ⺠Decreasing PA28 is a possible mechanism by which NO inhibits neointimal hyperplasia.
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Authors
Nick D. Tsihlis, Muneera R. Kapadia, Ashley K. Vavra, Qun Jiang, Bo Fu, Janet Martinez, Melina R. Kibbe,