Article ID Journal Published Year Pages File Type
10835122 Nitric Oxide 2012 5 Pages PDF
Abstract
► It was investigated the involvement of NO/cGMP/KATP in NA-induced antinociception. ► The rat paw PGE2-induced hyperalgesia and pressure test was used. ► l-NOarg and glibenclamide antagonized the antinociception effect induced by NA. ► ODQ antagonized and zaprinast potentiated the NA-induced antinociception. ► NA induces peripheral antinociceptive effect by activation of NO/cGMP/KATP pathway.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Noradrenaline activates the NO/cGMP/ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats
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