Cardiovascular effects and molecular targets of resveratrol

Article ID	Journal	Published Year	Pages	File Type
10835132	Nitric Oxide	2012	9 Pages	PDF

Abstract

âº Resveratrol possesses multiple protective effective against cardiovascular diseases. âº The underlying mechanisms are complex. âº We summarize the cardiovascular effects of resveratrol with emphasis on the molecular targets and the signaling cascades.

Keywords

VCAM-1 PON eNOS STZ PKC SOD1 PGC-1α NAMPT NRF-1 TFAM Heme oxygenase-1 SOD2 BH4 tetrahydrobiopterin GTP cyclohydrolase I T2DM CREB GCLC GPx1 oxLDL SERCA2a Trx-1 GRx SOD3 Ref-1 NQO GCH1 PBEF Nuclear factor-E2-related factor-2 TNF extracellular SOD COX-1 AMPK Sirt1 PI3K ADMA 4-HNE SMC Nrf2 HO-1 ICAM-1 iNOS TBARS 4-hydroxy-2-nonenal AMP-activated protein kinase I/R NAD(P)H:quinone oxidoreductase inducible NO synthase NOx ROS Myocardial infarction Apoe apolipoprotein E streptozotocin Vascular inflammation endothelial NO synthase NADPH oxidase ischemia–reperfusion cardiovascular disease Oxidative stress Thioredoxin-1 asymmetric dimethylarginine Type 2 diabetes mellitus Resveratrol Smooth muscle cells cyclooxygenase 1 nuclear respiratory factor-1 mitochondrial transcription factor A antioxidant response element Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)tumor necrosis factor Keap-1 Phosphatidylinositol 3-kinase LAD Oxidized low-density lipoprotein copper/zinc superoxide dismutase thiobarbituric acid-reactive substances Intercellular adhesion molecule 1 vascular cell adhesion molecule-1 Nitric oxide nicotinamide phosphoribosyltransferase ARE Paraoxonase cAMP response element-binding protein Protein kinase C left anterior descending coronary artery caveolin-1 Cav-1 Glutamate cysteine ligase catalytic subunit glutathione peroxidase 1 Glutaredoxin Reactive oxygen species Estrogen receptor