Pain and analgesia: The dual effect of nitric oxide in the nociceptive system

Article ID	Journal	Published Year	Pages	File Type
10835162	Nitric Oxide	2011	12 Pages	PDF

Abstract

âº Nitric oxide plays a complex and diverse role in the modulation of pain. âº This review aims to present data about the dual effect of NO on pain pathway. âº The molecular mechanisms involved in these effects. âº The potential use of nitric oxide in pain therapy.

Keywords

SGC PGE2 eNOS AMPA pKa IL-1β IL-10 NMDA N-methyl-d-aspartate PAG nNOS PKC 7-NI PKG PPAR-γ ODQ PGI2 L-NMMA SIN-1 i.pl.PGH PI3Kγ CNGS S-nitroso-N-acetylpenicillamine Intraplantar NO3-dbcGMP iNOS NSAID cGMP PDE COX NOS TNFα CFA 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one 3-morpholinosydnonimine L-NIO 7-nitroindazole complete Freund’s adjuvant l-NAME Nω-nitro-l-arginine methyl ester neuronal NOS inducible NOS Adenosine Triphosphate ATP cyclooxygenase ACh Akt Dual effect Acetylcholine α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid Arachidonic acid gamma-aminobutyric acid endothelial NOS Interleukin-10 Interleukin-1 beta Analgesia tumor necrosis factor-alpha Soluble guanylyl cyclase Non-steroidal anti-inflammatory drugs Pain CNS central nervous system SNAP Phosphodiesterases Nitrate Nitrite Nitric oxide nitric oxide synthase protein kinase A protein kinase B protein kinase G Protein kinase C cGMP-dependent protein kinase prostacyclin Prostaglandin E2 prostaglandin GABA cyclic guanosine 3′,5′-monophosphate peroxisome proliferator activated receptors