Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells

Article ID	Journal	Published Year	Pages	File Type
10835175	Nitric Oxide	2011	6 Pages	PDF

Abstract

âº NO promotes nicotine-mediated ERK1/2 activation. âº NO alone does not activate ERK1/2. âº NO-induced redox reaction enables nicotine-mediated ERK1/2 activation. âº NO-cGMP signaling does not activate nicotine-mediated ERK1/2. âº NO enhances nicotine-induced Ca2+ influx.

Keywords

EGF-R PKG ERK nAChR PKC nNOS MAPK PC12 cells neuronal nitric oxide synthase ERK phosphorylation Nitric oxide Nicotine Redox reactions protein kinase G Protein kinase C mitogen-activated protein kinase extracellular signal-regulated kinase nicotinic acetylcholine receptor Epidermal growth factor receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells

Authors

Yoshiaki Miyamoto, Ryosuke Sakai, Chiharu Maeda, Tsuyoshi Takata, Hideshi Ihara, Yukihiro Tsuchiya, Yasuo Watanabe,