| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835178 | Nitric Oxide | 2011 | 7 Pages |
Abstract
⺠Within pulmonary epithelial cells the nitrated fatty acid, ⺠nitrolinoleate, inhibits calcium influx. ⺠Inhibition of calcium influx does not occur through an NO-cGMP pathway. ⺠Treatment of pulmonary epithelial cells results in the activation of the MAP Kinase Erk. ⺠Nitrolinoleate effects in epithelial cells are PKC-dependent. ⺠Nitrolinoleate binds to PKCzeta, potentially via Michael addition, resulting in translocation to the membrane and activation.
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Authors
Chang-Jiang Guo, Francisco J. Schopfer, Linda Gonzales, Ping Wang, Bruce A. Freeman, Andrew J. Gow,