| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10835617 | Peptides | 2012 | 9 Pages |
Abstract
⺠Induction of endothelial B1R expression mediates portal vein contraction. ⺠Endothelial B1R expression is dependent of phosphorylation level of PI3K. ⺠PKC and PI3K regulate activation of transcription factors, CREB and AP-1, but not NF-κB in portal vein contraction. ⺠The COX-2 expression and activity are increased in the portal endothelium after in vitro incubation. ⺠Stimulation of endothelial B1R raises PLA2/COX-2-derived TXA2 levels in the portal vein.
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Authors
Fernanda L. Basei, Daniela A. Cabrini, Cláudia P. Figueiredo, Stefânia Forner, Daniela B. Hara, Andrey F.Z. Nascimento, Graziela S. Ceravolo, Maria Helena C. Carvalho, Michael Bader, Rodrigo Medeiros, João B. Calixto,