The bioactive peptides salusins and apelin-36 are produced in human arterial and venous tissues and the changes of their levels during cardiopulmonary bypass

► Immunoreactive salusin α and β and apelin-36 were detected in human the arteries and veins. ► The locally produced salusin-α and β might regulate the local function of those tissues. ► The amount of salusin-β in the circulation was 5-6 times larger than that of salusin-α. ► Salusins and apelin-36 might be important markers in the cardiopulmonary bypass follow up.